|
|
vindolidine + 2-oxoglutarate + O2 <=> deacetylvindorosine + succinate + CO2
|
1.14.11.20
deacetoxyvindoline 4-hydroxylase
|
–
|
| |
MetaCyc:
RXN-18623
|
|
|
|
S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine <=> S-adenosyl-L-homocysteine + deacetoxyvindoline + H+
|
2.1.1.99
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
|
–
|
| |
BRENDA:
BR43938
KEGG:
R04013
MetaCyc:
2.1.1.99-RXN
|
|
|
|
deacetoxyvindoline + 2-oxoglutarate + O2 <=> deacetylvindoline + succinate + CO2
|
1.14.11.20
deacetoxyvindoline 4-hydroxylase
|
–
|
| |
BRENDA:
BR40516
KEGG:
R05857
MetaCyc:
1.14.11.20-RXN
|
|
|
|
16-methoxy-2,3-dihydro-3-hydroxytabersonine + acceptor <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced_acceptor
|
1.1.99.41
3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
|
–
|
| |
BRENDA:
BR52126
KEGG:
R11777
MetaCyc:
RXN-18618
|
|
|
|
vindoline + Catharanthine + H2O2 <=> alpha-3,4''-anhydrovinblastine_radical + H2O
|
1.11.1
|
–
|
| |
MetaCyc:
RXN-8201
|
|
|
|
S-adenosyl-L-methionine + 16-hydroxytabersonine <=> H+ + S-adenosyl-L-homocysteine + 16-methoxytabersonine
|
2.1.1.94
tabersonine 16-O-methyltransferase
|
–
|
| |
BRENDA:
BR43933
KEGG:
R05885
MetaCyc:
2.1.1.94-RXN
|
|
|
|
deacetylvindoline + acetyl-CoA <=> vindoline + CoA
|
2.3.1.107
deacetylvindoline O-acetyltransferase
|
–
|
| |
BRENDA:
BR43971
KEGG:
R03230
MetaCyc:
2.3.1.107-RXN
SABIO-RK:
3056
|
|
|
|
dihydroprecondylocarpine_acetate_(enamine_form) <=> dehydrosecodine + acetate + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-19973
|
|
|
|
vinblastine + O2 <=> vincristine + H2O + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-18625
|
|
|
|
deacetylvindorosine + acetyl-CoA <=> vindorosine + CoA
|
2.3.1.107
deacetylvindoline O-acetyltransferase
|
–
|
| |
MetaCyc:
RXN-18624
|
|
|
|
strictosidine_aglycone <=> cathenamine + H2O
|
not assigned
|
–
|
| |
MetaCyc:
RXN-8223
|
|
|
|
alpha-3,4''-anhydrovinblastine + H2O <=> vinblastine
|
not assigned
|
–
|
| |
KEGG:
R05859
MetaCyc:
RXN-12023
|
|
|
|
16-methoxytabersonine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.50
tabersonine 3-oxygenase
|
–
|
| |
MetaCyc:
RXN-18616
|
|
|
|
tabersonine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.50
tabersonine 3-oxygenase
|
–
|
| |
MetaCyc:
RXN-18615
|
|
|
|
dehydrosecodine <=> tabersonine
|
not assigned
|
–
|
| |
MetaCyc:
RXN-19974
|
|
|
|
dihydroprecondylocarpine_acetate <=> dihydroprecondylocarpine_acetate_(enamine_form)
|
not assigned
|
–
|
| |
MetaCyc:
RXN-19977
|
|
|
|
stemmadenine_acetate + O2 <=> precondylocarpine_acetate + H2O2
|
1.21.3.M1
|
–
|
| |
MetaCyc:
RXN-19972
|
|
|
|
alpha-3,4''-anhydrovinblastine_radical + reduced_acceptor <=> alpha-3,4''-anhydrovinblastine + acceptor
|
not assigned
|
–
|
| |
MetaCyc:
RXN-20001
|
|
|
|
Stemmadenine + NADP+ <=> intermediate_II + NADPH + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-19983
|
|
|
|
tabersonine + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 16-hydroxytabersonine + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.103
tabersonine 16-hydroxylase
|
–
|
| |
MetaCyc:
1.14.13.73-RXN
|
|
|
|
cathenamine <=> 4,21-Dehydrogeissoschizine
|
not assigned
|
–
|
| |
KEGG:
R05846
MetaCyc:
RXN-19979
|
|
|
|
intermediate_II + NADP+ <=> intermediate_I + NADPH + H+
|
not assigned
|
–
|
| |
MetaCyc:
RXN-19984
|
|
|
|
dehydrosecodine <=> Catharanthine
|
not assigned
|
–
|
| |
MetaCyc:
RXN-19975
|
|
|
|
Stemmadenine + acetyl-CoA <=> stemmadenine_acetate + CoA
|
2.3.1.M59
|
–
|
| |
MetaCyc:
RXN-19971
|
|
|
|
dihydroprecondylocarpine_acetate + NADP+ <=> precondylocarpine_acetate + NADPH + H+
|
1.3.1.M18
|
–
|
| |
MetaCyc:
RXN-19978
|
|
|
|
strictosidine + H2O <=> strictosidine_aglycone + D-glucose
|
3.2.1.105
3alpha(S)-strictosidine beta-glucosidase
3.2.1.125
raucaffricine beta-glucosidase
|
–
–
|
| |
BRENDA:
BR15979
KEGG:
R03820
MetaCyc:
STRICTOSIDINE-BETA-GLUCOSIDASE-RXN
|
|
|
|
S-adenosyl-L-methionine + (3R)-3-hydroxy-2,3-dihydrotabersonine <=> S-adenosyl-L-homocysteine + vindolidine + H+
|
2.1.1.99
3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
|
–
|
| |
MetaCyc:
RXN-18622
|
|
|
|
19E-geissoschizine + H+ + O2 + reduced_[NADPH-hemoprotein_reductase] <=> intermediate_I + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.19.M23
|
–
|
| |
MetaCyc:
RXN-19985
|
|
|
|
19E-geissoschizine + NADP+ <=> 4,21-Dehydrogeissoschizine + NADPH
|
1.3.1.36
geissoschizine dehydrogenase
|
–
|
| |
MetaCyc:
GEISSOSCHIZINE-DEHYDROGENASE-RXN
|
|
|
|
(3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor <=> (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced_acceptor
|
1.1.99.41
3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
|
–
|
| |
BRENDA:
BR52127
KEGG:
R11802
MetaCyc:
RXN-18621
|
|
